Search results for "2-a]azepines"

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Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells

2022

Searching for new small molecules as photosensitizing agents, we have developed a class of twenty-five pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepines with a good substitution pattern defining a versatile synthetic pathway to approach the title ring system. All compounds were evaluated for their photocytotoxicity on a triple negative human breast cancer cell line (MDA-MB-231) in the dark and under UVA light (2.0 J/cm2). The most effective compounds exhibited a photoantiproliferative activity with IC50 values up to nanomolar ranges. Interestingly, these new developed compounds showed high selectivity towards cancerous cells with respect to non-cancerous ones. Moreover, fo…

PharmacologyMDA-MB-231Triple negative human breast cancerOrganic ChemistryPhototoxic activityIndolizinesAntineoplastic AgentsApoptosisTriple Negative Breast Neoplasms4-g]indolizinespyrimido[4General MedicineAzepinespyrimido[54-g]indolizinespyrimido[45-c]pyrrolo[12-a]azepinesTriple negative human breast cancerMDA-MB-231Photosensitizing agentsPhototoxic activitypyrimido[5Photosensitizing agents5-c]pyrrolo[1pyrimido[45-c]pyrrolo[12-a]azepinesCell Line Tumor2-a]azepinesTriple negative human breast cancerMDA-MB-231Photosensitizing agentsPhototoxic activityDrug DiscoveryHumanspyrimido[54-g]indolizines
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